The Talis Advantage

Talis develops revolutionary technologies to address critical clinical needs. Technologies at the core of our solutions are both simple and powerful.

Simplified and Automated
Sample Prep with Talis

Modular fluid management of samples and reagents in a single-use cartridge.

Splitting/ Subtraction

Fractionate fluid in partitions for parallel treatment

Addition

Automated metering of samples and reagents

Mixing

Addition of preloaded internal standards and multiple reagents

Target Amplification

Amplify and label multiple molecules of interest

Lysis and Extraction

Lysis and extraction of nucleic acids from any microbe or cell

Valving

Proprietary valving manages test workflow

Sensitive Detection Methods

Combination of SlipChips, Fluorescence and Bright Field real-time imaging enable unlimited test formats in a compact platform.

Detection

Direct imaging or sensing of compartments for rapid qualitative assessment and multiplexing.

Digital
Quantification

SlipChip™ sample partitioning in hundreds to thousands of fractions allows accurate quantification of biomolecules within 20% variance. [3]

Real-time
Quantification

Real-time quantification of individual compartments ensures specificity of test and enables safe multiplexing.

Multimode
Imaging

Multimode Bright Field / Fluorescence imaging enables parallel molecular, chemical and inmunoassay testing.

Test Innovation

A combination of proprietary technologies, unique capabilities and a strong drive to revolutionize medicine give Talis a pathway to develop novel solutions to big clinical challenges.

Molecular Biology

Highly evolved isothermal amplification chemistries.

Bioinformatics Design Pipeline

Proprietary primer and assay optimization bioinformatics pipeline reduces development cycles and optimizes for both sensitivity and specificity.

Design-Build-Test

We embrace principles of Rapid Prototyping and Agile development to develop revolutionary integrated systems in the biomedical field.

References

  1. Rapid pathogen-specific phenotypic antibiotic susceptibility testing using digital LAMP quantification in clinical samples. Nathan G. Schoepp1,*, Travis S. Schlappi1,*, Matthew S. Curtis1, Slava S. Butkovich1, Shelley Miller2, Romney M. Humphries2 and Rustem F. Ismagilov1,† See all authors and affiliations. Science Translational Medicine 04 Oct 2017: Vol. 9, Issue 410, eaal3693 DOI: 10.1126/scitranslmed.aal3693
  2. Nathan G. Schoepp, Eugenia M. Khorosheva, Travis S. Schlappi, Matthew S. Curtis, Romney M. Humphries, Janet A. Hindler and Rustem F. Ismagilov. 2016. “Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility After Only 15 Minutes of Antibiotic Exposure.” Angewandte Chemie. Published online June 30, 2016. doi: 10.1002/anie.201602763. Read More
  3. Liang Ma, Jungwoo Kim, Roland Hatzenpichler, Mikhail A. Karymov, Nathaniel Hubert, Ira M. Hanan, Eugene B. Chang, and Rustem F. Ismagilov. “Gene-targeted Microfluidic Cultivation Validated by Isolation of a Gut Bacterium Listed in Human Microbiome Project’s Most Wanted taxa.” PNAS 2014 111(27):9768-9773. Read More
  4.  David A. Selck, Mikhail A. Karymov, Bing Sun, and Rustem F. Ismagilov, “Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements,” Analytical Chemistry 2013 85: 11129-11136, video s1 link. Read More
  5. Feng Shen, Elena K. Davydova, Wenbin Du, Jason E. Kreutz, Olaf Piepenburg, and Rustem F. Ismagilov, “Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip,” Analytical Chemistry 2011 83:3533-3540. Read More
  6.  Feng Shen, F. et al. Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load. J. Am. Chem. Soc. 133, 17705–17712 (2011). Read More
  7.  Feng Shen, Wenbin Du, Jason E. Kreutz, Alice Fok, and Rustem F. Ismagilov, “Digital PCR on a SlipChip,” Lab Chip 2010 10: 2666-2672, cover (291 KB). Read More
  8.  Feng Shen, Wenbin Du, Elena K. Davydova, Mikhail A. Karymov, Janmajay Pandey, and Rustem F. Ismagilov, “Nanoliter Multiplex PCR Arrays on a SlipChip,” Analytical Chemistry2010 82:4606-4612. Read More

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