Talis develops revolutionary technologies to address critical clinical needs. Technologies at the core of our solutions are both simple and powerful.
Simplified and Automated
Sample Prep with Talis
Modular fluid management of samples and reagents in a single-use cartridge.
Fractionate fluid in partitions for parallel treatment
Automated metering of samples and reagents
Addition of preloaded internal standards and multiple reagents
Amplify and label multiple molecules of interest
Lysis and Extraction
Lysis and extraction of nucleic acids from any microbe or cell
Proprietary valving manages test workflow
Sensitive Detection Methods
Combination of SlipChips, Fluorescence and Bright Field real-time imaging enable unlimited test formats in a compact platform.
Direct imaging or sensing of compartments for rapid qualitative assessment and multiplexing.
SlipChip™ sample partitioning in hundreds to thousands of fractions allows accurate quantification of biomolecules within 20% variance. 
Real-time quantification of individual compartments ensures specificity of test and enables safe multiplexing.
Multimode Bright Field / Fluorescence imaging enables parallel molecular, chemical and inmunoassay testing.
A combination of proprietary technologies, unique capabilities and a strong drive to revolutionize medicine give Talis a pathway to develop novel solutions to big clinical challenges.
Highly evolved isothermal amplification chemistries.
Proprietary primer and assay optimization bioinformatics pipeline reduces development cycles and optimizes for both sensitivity and specificity.
We embrace principles of Rapid Prototyping and Agile development to develop revolutionary integrated systems in the biomedical field.
- Rapid pathogen-specific phenotypic antibiotic susceptibility testing using digital LAMP quantification in clinical samples. Nathan G. Schoepp1,*, Travis S. Schlappi1,*, Matthew S. Curtis1, Slava S. Butkovich1, Shelley Miller2, Romney M. Humphries2 and Rustem F. Ismagilov1,† See all authors and affiliations. Science Translational Medicine 04 Oct 2017: Vol. 9, Issue 410, eaal3693 DOI: 10.1126/scitranslmed.aal3693
Nathan G. Schoepp, Eugenia M. Khorosheva, Travis S. Schlappi, Matthew S. Curtis, Romney M. Humphries, Janet A. Hindler and Rustem F. Ismagilov. 2016. “Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility After Only 15 Minutes of Antibiotic Exposure.” Angewandte Chemie. Published online June 30, 2016. doi: 10.1002/anie.201602763. Read More
Liang Ma, Jungwoo Kim, Roland Hatzenpichler, Mikhail A. Karymov, Nathaniel Hubert, Ira M. Hanan, Eugene B. Chang, and Rustem F. Ismagilov. “Gene-targeted Microfluidic Cultivation Validated by Isolation of a Gut Bacterium Listed in Human Microbiome Project’s Most Wanted taxa.” PNAS 2014 111(27):9768-9773. Read More
David A. Selck, Mikhail A. Karymov, Bing Sun, and Rustem F. Ismagilov, “Increased Robustness of Single-Molecule Counting with Microfluidics, Digital Isothermal Amplification, and a Mobile Phone versus Real-Time Kinetic Measurements,” Analytical Chemistry 2013 85: 11129-11136, video s1 link. Read More
Feng Shen, Elena K. Davydova, Wenbin Du, Jason E. Kreutz, Olaf Piepenburg, and Rustem F. Ismagilov, “Digital Isothermal Quantification of Nucleic Acids via Simultaneous Chemical Initiation of Recombinase Polymerase Amplification Reactions on SlipChip,” Analytical Chemistry 2011 83:3533-3540. Read More
Feng Shen, F. et al. Multiplexed quantification of nucleic acids with large dynamic range using multivolume digital RT-PCR on a rotational SlipChip tested with HIV and hepatitis C viral load. J. Am. Chem. Soc. 133, 17705–17712 (2011). Read More
Feng Shen, Wenbin Du, Elena K. Davydova, Mikhail A. Karymov, Janmajay Pandey, and Rustem F. Ismagilov, “Nanoliter Multiplex PCR Arrays on a SlipChip,” Analytical Chemistry2010 82:4606-4612. Read More